The cruelty in the world saddens me incredibly.

世间的残酷令我悲伤不已。

It saddens me that this network...

我感到很伤心，这个网络。

It saddens me, but I know why I took that decision.

这令我很伤心，不过我清楚自己为何作那个决定。

It saddens me that I don't understand why he is sad.

我也变的难过起来因为我不知道为什么他那么伤心。

You can't begin to imagine how much that saddens me.

你都无从想象这让我有多悲伤。

This has been the hardest decision of my life and one that saddens me deeply.

这是我一生中最艰难的决定，也是最让我难过的决定。

The fact that my genius goes unrecognized saddens me, but no longer surprises.

天赋得不到承认使我沮丧，但也使我不再大惊小怪。

As much as that saddens me, I think really time for me to say goodbye to you.

虽然真的让我非常伤心，但我真的必须要说再见了。

It saddens me because I know them in other corners of their life as cheerful people.

这使我感到悲哀，因为我知道他们在生活的其它方面都是些高高兴兴的人。

It saddens me to think that such a simple phrase can have such a devastating impact.

我感到很伤心难过，因为就是如此简单的几个字却具有如此破坏性的影响。

What saddens me most is when I read about human beings ill-treating other human beings.

使我最难过的是，当我读到关于人类如何虐待其他人类。

What saddens me most, Sir, is how much you will be missing if you turn your back on science.

殿下，最让我感到悲哀的是，如果您拒绝科学，您将失去多少。

Great architecture can never be fully conveyed through a television screen, of course, and it saddens me that so many Americans will experience the building only via satellite.

伟大建筑不能得到充分转达了通过电视屏幕，当然，它伤心我说，这么多的美国人将建设的经验，只有通过卫星。