Scientists have known that the protein complex known as FANCI-FANCD2 responds to DNA damage and repairs cross-linking, but the details of how the complex works have been unknown.
科学家早已确信存在一种称为FANCI-FANCD2的蛋白复合物,该复合体与DNA损伤及交联修复有并,至于其作用机制尚未可知。
Beyond these details, the researchers knew that repair involves snipping out and replacing the damaged DNA, but didn't know if FANCI and FANCD2 play a role in this molecular tailoring.
除了这些细节,研究者还了解,修复过程包括修剪和替换损坏的DNA,但是不了解FANCI和FANCD 2是否在分子裁剪过程中起作用。